罗沙替丁是醋酸罗沙替丁盐酸盐的活性代谢物，是组胺 H2 受体拮抗剂。
| Cas No. | 78273-80-0 |
| 别名 | 罗沙替丁 |
| Canonical SMILES | O=C(CO)NCCCOC1=CC=CC(CN2CCCCC2)=C1 |
| 分子式 | C17H26N2O3 |
| 分子量 | 306.4 |
| 溶解度 | DMSO: up to 25 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Roxatidine is a histamine H2receptor antagonist and major active metabolite of roxatidine acetate .1Roxatidine reduces histamine-induced adenylate cyclase production in guinea pig parietal cells (IC50= 0.8 µM). It inhibits histamine-induced hydrogen ion accumulation in the same cells (pA2= 7.03). Roxatidine (200 mg/kg) reduces small intestinal lesion area in a rat model of gastric mucosal injury induced by indomethacin .2 1.Sewing, K.-F., Beil, W., and Hannemann, H.Comparative pharmacology of histamine H2-receptor antagonistsDrugs35(Suppl. 3)25-29(1988)
2.Umegaki, E., Yoda, Y., Tokioka, S., et al.Protective effect of roxatidine against indomethacin induced small intestinal mucosal injury in ratsJ. Gastroenterol. Hepatol.25(Suppl. 1)S35-S40(2010) |
