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Melittin(trifluoroacetate salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Melittin(trifluoroacetate salt)图片
包装与价格：
包装价格(元)
500 µg询价
1mg询价
5mg询价

The principal cytotoxic component of bee venom
Canonical SMILESNC([C@H](CCC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@H](CO)NC([C@@]([C@H](CC)C)([H])NC([C@H](CC(C)C)NC([C@@H](NC([C@@H]1CCCN1C([C@H](CC(C)C)NC(CNC([C@@]([C@@H](C)O)([H])NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@@H](NC(CNC([C@@]([C@H](CC)C)([H])NC(CN[H])=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)CC2=CNC3=C2C=CC=C3)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
分子式C131H229N39O31• XCF3COOH
分子量2846.5
溶解度DMF: 25 mg/ml,DMSO: 25 mg/ml,PBS (pH 7.2): 3 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Melittin is a small protein that is the principal cytotoxic component of venom of the honey bee,A. mellifera.1Structurally, melittin consists of two α-helical segments forming a bent rod, with hydrophilic residues on the convex side and hydrophobic sites on the concave side.1,2This allows melittin molecules to assemble as tetramers on membrane surfaces and form pores, resulting in cell death. Bee venom is also known to stimulate phospholipase A2(PLA2) activity, and this may be linked to melittin-mediated pore production as well as the presence of low molecular weight PLA2enzymes in the venom.2,3Melittin also has antimicrobial properties, which, combined with its cytolytic properties, extends its potential for therapeutic applications.3

1.Terwilliger, T.C., and Eisenberg, D.The structure of melittin. II. Interpretation of the structureThe Journal of Biological Chemisty257(11)6016-6022(1982) 2.Kourie, J.I., and Shorthouse, A.A.Properties of cytotoxic peptide-formed ion channelsAmerican Journal of Physiology.Cell Physiology278C1063-C1087(2000) 3.Moreno, M., and Giralt, E.Three valuable peptides from bee and wasp venoms for therapeutic and biotechnological use: Melittin, apamin and mastoparanToxins71126-1150(2015)

 
 
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