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Hepcidin-25(trifluoroacetate salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Hepcidin-25(trifluoroacetate salt)图片
包装:100 µg
市场价:2786元

A peptide hormone
Canonical SMILESO=C(O)C[C@H](N[H])C(N[C@]([C@H](O)C)([H])C(N[C@@H](CC1=CNC=N1)C(N[C@H](C(N2CCC[C@H]2C(N[C@@](C(N[C@@H](CSSC[C@H](N3)C(N[C@@H](CCCCN[H])C(N[C@]([C@H](O)C)([H])C(O)=O)=O)=O)C(N[C@@](C(N[C@H](C(N[C@@H](CSSC[C@H](N4)C(N[C@@H](CSSC[C@H](N5)C3=O)C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CCCCN[H])C7=O)=O)=O)=O)=O)=O)C(N[C@@H](CSSC[C@H](N7)C(NCC(N[C@@H](CCSC)C5=O)=O)=O)C(NCC4=O)=O)=O)=O)CC8=CC=CC=C8)=O)([H])[C@@H](C)CC)=O)=O)([H])[C@@H](C)CC)=O)=O)CC9=CC=CC=C9)=O)=O)=O.OC(C(F)(F)F)=O
分子式C113H170N34O31S9• XCF3COOH
分子量2789.4
溶解度Water: 1mg/mL
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Hepcidin-25 is a peptide hormone that regulates iron homeostasis and has antibacterial activity.1It is predominantly synthesized by hepatocytes and secreted into the circulation. Hepcidin-25 binds to ferroportin, a membrane-bound iron exporter expressed by macrophages, enterocytes, and hepatocytes, inducing ferroportin internalization and degradation, which increases intracellular iron levels and decreases dietary iron absorption and plasma iron levels. It is bactericidal against multidrug-resistant clinical isolates of Gram-negative and Gram-positive bacteria, includingP. aeruginosa,E. coli,K. pneumoniae,S. aureus,S. epidermidis, andE. faecium, when used at concentrations ranging from 6.25 to 50 µg/ml.2Serum hepcidin-25 levels are increased in patients with chronic kidney disease (CKD).3

1.Kroot, J.J.C., Tjalsma, H., Fleming, R.E., et al.Hepcidin in human iron disorders: Diagnostic implicationsClin. Chem.57(12)1650-1669(2011) 2.Maisetta, G., Petruzzelli, R., Brancatisano, F.L., et al.Antimicrobial activity of human hepcidin 20 and 25 against clinically relevant bacterial strains: Effect of copper and acidic pHPeptides31(11)1995-2002(2010) 3.Tsuchiya, K., and Nitta, K.Hepcidin is a potential regulator of iron status in chronic kidney diseaseTher. Apher. Dial.17(1)1-8(2013)

 
 
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