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Rp-8-CPT-Cyclic AMP(sodium salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Rp-8-CPT-Cyclic AMP(sodium salt)图片
CAS NO:221905-35-7
包装与价格：
包装价格(元)
500μg询价
1mg询价

Rp-8-CPT-Cyclic AMP (sodium salt) 是一种 cAMP 类似物，是 cAMP 诱导的 cAMP 依赖性 PKA I 和 II 活化的有效竞争性拮抗剂。
Cas No.221905-35-7
化学名8-[(4-chlorophenyl)thio]-adenosine cyclic 3',5'-[hydrogen (R)-phosphorothioate], monosodium salt
Canonical SMILESO[C@H]1[C@H](N2C(SC3=CC=C(Cl)C=C3)=NC4=C2N=CN=C4N)O[C@H]5[C@H]1O[P@@](OC5)([S-])=O.[Na+]
分子式C16H14ClN5O5PS2•Na
分子量509.8
溶解度25mg/mL in DMSO, 30mg/mL in DMF, 0.5mg/mL in Ethanol
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Rp-8-CPT-cAMP is a structural combination of the lipophilic and non-hydrolyzable cAMP analogs, 8-CPT-cyclic AMP and Rp-cyclic AMPS .[1] It functions as a site-selective inhibitor of protein kinase A (PKA) type I and II, with preference towards site A of type I and site B of type II.2 By occupying cAMP binding sites at the regulatory subunit of PKA, Rp-8-CPT-cAMP prevents the kinase holoenzyme from dissociative activation.[2],[3]

Reference:
[1]. Schwede, F., Maronde, F., Genieser, H., et al. Cyclic nucleotide analogs as biochemical tools and prospective drugs. Pharmacology & Therapeutics 87(2), 199-226 (2000).
[2]. Dostmann, W.R., Taylor, S.S., Genieser, H.G., et al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J. Biol. Chem. 265(18), 10484-10491 (1990).
[3]. Gjertsen, B.T., Mellgran, G., Otten, A., et al. Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1β action. J. Biol. Chem. 270(35), 20599-20607 (1995).

 
 
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