咖啡醇是咖啡的主要成分之一，是一种咖啡特有的二萜。
| Cas No. | 469-83-0 |
| 别名 | 咖啡醇 |
| Canonical SMILES | O[C@]1(CO)C[C@]23[C@](CC[C@]1([H])C3)([H])[C@@](CCC4=C5C=CO4)(C)[C@]5([H])CC2 |
| 分子式 | C20H28O3 |
| 分子量 | 316.4 |
| 溶解度 | DMF: 12 mg/ml,DMF:PBS (pH 7.2) (1:50): 0.02 mg/ml,DMSO: 5 mg/ml,Ethanol: 5 mg/ml |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects[1]. References:
[1]. Shen T, et al. Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Biol Pharm Bull. 2010;33(1):128-32. |
