RU-302 是一种非选择性的TAM 抑制剂，阻断 TAM Ig1 胞外域和 Gas6 Lg 结构域之间的界面。RU-302 用低微摩尔 IC50 有效阻断 Gas6 诱导的 Axl 受体活化，并有效抑制肺癌肿瘤的生长。
| Cas No. | 1182129-77-6 |
| 分子式 | C24H24F3N3O2S |
| 分子量 | 475.53 |
| 溶解度 | DMSO : 100 mg/mL (210.29 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth[1]. [1]. Kimani SG, et al. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity. Sci Rep. 2017 Mar 8;7:43908. |
