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Terevalefim
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Terevalefim图片
CAS NO:1070881-42-3
包装与价格：
包装价格(元)
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Terevalefim (ANG-3777) 是一种干细胞生长因子 (HGF) 的类似物，选择性的激活 c-Met 受体。
Cas No.1070881-42-3
别名ANG-3777
分子式C9H8N2S
分子量176.24
溶解度DMSO : 100 mg/mL (567.41 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor[1][2].

Terevalefim (ANG-3777) (0-10 μM) significantly inhibited cancer cells proliferation in HUVECs[2].

Terevalefim (ANG-3777) decreases apoptosis, increases proliferation, and promotes organ repair and function in animal models[1].Terevalefim (ANG-3777, 40 mg/kg, IP) phosphorylates the c-Met receptor in rats[2].

[1]. Jonathan S Bromberg, et al. Renal Function Improvement Following ANG-3777 Treatment in Patients at High Risk for Delayed Graft Function After Kidney Transplantation. Transplantation. 2021 Feb 1;105(2):443-450.
[2]. Latha Paka, et al. The Effect of ANG-3777 on Hepatocyte Growth Factor Receptor, c-MET Signaling. American Transplant Society.

 
 
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