GFB-12811 是一种高选择性口服活性 CDK5 抑制剂，IC50 为 2.3 nM。GFB-12811 对其他测试激(CDK1/2/6/7/9) 具有高度选择性。
| Cas No. | 2775311-17-4 |
| 分子式 | C22H23F4N5O |
| 分子量 | 449.44 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | GFB-12811 is a high selective and orally active CDK5 inhibitor with an IC50 of 2.3 nM. GFB-12811 is highly selective over the other tested kinases (CDK1/2/6/7/9)[1]. [1]. Daniels MH, et al. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022;65(4):3575-3596. |
