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Hygromycin A
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Hygromycin A图片
CAS NO:6379-56-2
包装与价格：
包装价格(元)
1mg询价
5mg询价
10mg询价
25mg询价

An antibiotic
Cas No.6379-56-2
别名匀霉素
Canonical SMILESO[C@H]1[C@@]2([H])[C@@](OCO2)([H])[C@@H]([C@H]([C@H]1NC(/C(C)=C/C3=CC(O)=C(C=C3)O[C@H]4[C@@H](O)[C@H](O)[C@@H](C(C)=O)O4)=O)O)O
分子式C23H29NO12
分子量511.5
溶解度DMF: 16 mg/mL,DMSO: 10 mg/mL,Ethanol: 12 mg/mL,PBS (pH 7.2): 10 mg/mL
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Hygromycin A is an antibiotic originally isolated fromS. hygroscopicus.1It is active against numerous spirochete bacteria, includingT. pallidum,L. biflexa, and four strains ofB. burgdorferi(MICs = 0.03-4 µg/ml for all). Hygromycin A binds to the peptidyl transferase center (PTC) in the 70S ribosomal subunit to inhibit protein synthesis. It completely eliminates bacterial infection in skin biopsies fromB. burgdorferi-infected mice in a model of acute Lyme disease when administered at doses ranging from 50 to 250 mg/kg twice per day.

1.Leimer, N., Wu, X., Imai, Y., et al.A selective antibiotic for Lyme diseaseCell184(21)5405-5418.e5416(2021)

 
 
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