An internal standard for the quantification of thymidine
| Cas No. | 347841-67-2 |
| 别名 | 胸苷-ALPHA,ALPHA,ALPHA,6-D4,DThyd-d4; NSC 21548-d4 |
| Canonical SMILES | OC[C@H]1O[C@](N2C(NC(C(C([2H])([2H])[2H])=C2[2H])=O)=O)([H])C[C@@H]1O |
| 分子式 | C10H10D4N2O5 |
| 分子量 | 246.3 |
| 溶解度 | DMF: 16 mg/mL,DMSO: 10mg/mL,PBS (pH 7.2): 5mg/mL |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Thymidine-d4is intended for use as an internal standard for the quantification of thymidine by GC- or LC-MS. Thymidine is a pyrimidine nucleoside composed of a deoxyribose sugar and thymine base.1It is phosphorylated by thymidine kinase 2 (TK2) in mitochondria to form deoxythymidine monophosphate .2Oral administration of thymidine in combination with deoxycytidine increases lifespan in aTk2 H126Nknock-in mouse model of TK2 deficiency. 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Biochemistry(2002)
2.Lopez-Gomez, C., Levy, R.J., Sanchez-Quintero, M.J., et al.Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiencyAnn. Neurol.81(5)641-652(2017) |
