| 产品描述 | Uridine-d2is intended for use as an internal standard for the quantification of uridine by GC- or LC-MS. Uridine is a pyrimidine nucleoside composed of uracil and ribose.1It forms complementary base pairs with adenosine in RNA.2Uridine can be catabolized to uracilviauridine phosphorylase, and it can be phosphorylated to uridine-5’-monophosphate by uridine-cytidine kinase (UCK).1,3It is replaced with thymidine in DNA.4 1.Yamamoto, T., Koyama, H., Kurajoh, M., et al.Biochemistry of uridine in plasmaClin. Chim. Acta412(19-20)1712-1724(2011)
2.Zinshteyn, B., and Nishikura, K.Adenosine-to-inosine RNA editingWiley Interdiscip. Rev. Syst. Biol. Med.1(2)202-209(2009)
3.Van Rompay, A.R., Norda, A., LindÉn, K., et al.Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinasesMol. Pharmacol.59(5)1181-1186(2001)
4.Knoop, V.When you can’t trust the DNA: RNA editing changes transcript sequencesCell. Mol. Life Sci.68(4)567-586(2011) |
