| CAS NO: | 1675203-82-3 |
| 规格: | ≥98% |
| Molecular Weight (MW) | 499.51 |
|---|---|
| Formula | C27H27F2NO5 |
| CAS No. | 1675203-82-3 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 10mM |
| Water: N/A | |
| Ethanol: N/A | |
| Chemical Name | (S)-4-((4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2,5-difluorobenzyl)amino)-3-hydroxybutanoic acid |
| Synonyms | BMS-200; BMS 200; BMS200 |
| SMILES Code |
| In Vitro | In vitro activity: BMS-1001 is a novel and potent small molecule inhibitor of the PD-1/PD-L1 protein protein interaction with IC50 value of 2.25 nM in cell free assays. Kinase Assay: BMS disclosed recently the first nonpeptidic small molecule inhibitors against the PD-1/PD-L1 pathway that showed the activity in a homogeneous time-resolved fluorescence (HTRF) binding assay; however no further data supporting their activity were provided. Cell Assay: |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References |
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