An internal standard for the quantification of N’-nitrosonornicotine
| Cas No. | 66148-19-4 |
| 别名 | 氘代N-亚硝基降烟碱(NNN) |
| Canonical SMILES | O=NN1C(C2=C([2H])N=C([2H])C([2H])=C2[2H])CCC1 |
| 分子式 | C9H7D4N3O |
| 分子量 | 181.2 |
| 溶解度 | Chloroform: slightly soluble,Methanol: slightly soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | N′-Nitrosonornicotine-d4is intended for use as an internal standard for the quantification of N′-nitrosonornicotine by GC- or LC-MS. N′-Nitrosonornicotine is a tobacco-specific N-nitrosamine and carcinogen that has been found in unburned tobacco and cigarette smoke.1It induces the formation of DNA adducts in isolated rat nasal mucosa and esophagus. N′-Nitrosonornicotine induces tumor formation in rat esophagus and nasal cavity, mouse lung, forestomach, and trachea, and hamster trachea and forebrain. Urinary levels of N′-nitrosonornicotine are positively correlated with the risk of esophageal cancer in smokers.2 1.Hecht, S.S.Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosaminesChem. Res. Toxicol.11(6)559-603(1998)
2.Yuan, J.-M., Knezevich, A.D., Wang, R., et al.Urinary levels of the tobacco-specific carcinogen N’-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokersCarcinogenesis32(9)1366-1371(2011) |
