Abemaciclib metabolite M18 hydrochloride

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包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	询价
5mg	询价
10mg	询价
25mg	询价
50mg	询价
100mg	询价

Abemaciclib metabolite M18 (LSN3106729) hydrochloride，Abemaciclib 的代谢物，是一种具有抗肿瘤活性的 CDK 抑制剂。Abemaciclib metabolite M18 hydrochloride 和 CRBN 配体可用于设计 PROTAC CDK4/6 降解剂。

别名	LSN3106729 hydrochloride
分子式	C₂₅H₂₉ClF₂N₈O
分子量	531
溶解度	DMSO : 125 mg/mL (235.40 mM; Need ultrasonic)\|Water : 100 mg/mL (188.32 mM; Need ultrasonic)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib , is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1]. [1]. Edward S. Kim, et al. Abemaciclib in Combination with Single-Agent Options in Patients with Stage IV Non-Small Cell Lung Cancer: A Phase Ib Study. [2]. Nathanael Gray, et al. Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods of use. WO2017185031A1. $