| CAS NO: | 1222800-79-4 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 50mg | 询价 |
| 100mg | 询价 |
| 250mg | 询价 |
| 500mg | 询价 |
| Molecular Weight (MW) | 349.43 |
|---|---|
| Formula | C21H23N3O2 |
| CAS No. | 1222800-79-4 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 43 mg/mL (123.0 mM) |
| Water:<1 mg/mL | |
| Ethanol: 3 mg/mL (8.6 mM) | |
| SMILES | O=C(NCCCN(C)C)C1=CC=C(C2=CC(O)=C3N=CC=CC3=C2)C=C1 |
| Synonyms | CID 44143209; CID-44143209; CID44143209; ML 324; ML-324; ML324 Chemical Name: N-[3-(dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)-benzamide InChi Key: QDBVSOZTVKXUES-UHFFFAOYSA-N InChi Code: InChI=1S/C21H23N3O2/c1-24(2)12-4-11-23-21(26)16-8-6-15(7-9-16)18-13-17-5-3-10-22-20(17)19(25)14-18/h3,5-10,13-14,25H,4,11-12H2,1-2H3,(H,23,26) SMILES Code: O=C(NCCCN(C)C)C1=CC=C(C2=CC(O)=C3N=CC=CC3=C2)C=C1 |
| In Vitro | In vitro activity: ML324 exhibits good Caco-2 cell permeability, and possesses excellent microsomal stability in the presence of both mouse and rat liver microsomes. ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection by inhibiting viral IE gene expression. Kinase Assay: ML324 is a potent and cell-permeable JMJD2 demethylase inhibitor (IC50 = 920 nM). Cell Assay: ML324 acted as an antiviral agent that effectively inhibited HSV and hCMV IE gene expression in HFF and MRC-5 cells, resulted in suppression of HSV plaques formation and inhibition of HSV infection spread. |
|---|---|
| In Vivo | In a mouse ganglia explant model of latently infected mice, ML324 suppresses the formation of HSV plaques, and blocks HSV-1 reactivation |
| Animal model | Mice |
| Formulation & Dosage | N/A |
| References | Probe Reports from the NIH Molecular Libraries Program; |
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