| CAS NO: | 622855-37-2 |
| 包装: | 1mg |
| 市场价: | 1530元 |
| Cas No. | 622855-37-2 |
| Canonical SMILES | OC1=CC=C(N([H])C2=C3C4=C(C(N([H])C4=O)=O)C(C5=C(Cl)C=CC=C5)=C2)C3=C1 |
| 分子式 | C20H11ClN2O3 |
| 分子量 | 362.8 |
| 溶解度 | DMSO: 10 mg/ml,Ethanol: 10 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Wee1 inhibitor is an inhibitor of the checkpoint kinase Wee1 (IC50= 11 nM).1It is selective for Wee1 over checkpoint kinase 1 (Chk1; IC50= 440 nM). Wee1 inhibitor also inhibits the ATPase activity of LptB, an enzyme involved in the transport and assembly of LPS (IC50= 25 µM for theE. colienzyme).2 1.Palmer, B.D., Thompson, A.M., Booth, R.J., et al.4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitutionJ. Med. Chem.49(16)4896-4911(2006) 2.Gronenberg, L.S., and Kahne, D.Development of an activity assay for discovery of inhibitors of lipopolysaccharide transportJ. Am. Chem. Soc.132(8)2518-2519(2010) |
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