Parsaclisib(INCB050465)

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CAS NO:

1426698-88-5

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	询价
5mg	询价
10mg	询价
25mg	询价
50mg	询价
100mg	询价

Parsaclisib (INCB050465) (INCB050465) 是一种有效的、选择性的、具有口服活性的 PI3Kδ 抑制剂；在 1 mM ATP 下，IC50 为 1 nM。 Parsaclisib (INCB050465) 的选择性比其他 PI3K I 类异构体高约 20000 倍。 Parsaclisib (INCB050465) 可用于研究复发或难治性 B 细胞恶性肿瘤。

Cas No.	1426698-88-5
别名	INCB050465
Canonical SMILES	CCOC1=C([C@@H](C2)CNC2=O)C(F)=C(Cl)C=C1[C@@H](N3C4=NC=NC(N)=C4C(C)=N3)C
分子式	C₂₀H₂₂ClFN₆O₂
分子量	432.88
溶解度	DMSO : 125 mg/mL (288.76 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Parsaclisib is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases. Parsaclisib (INCB050465) is a potent and selective PI3Kδ with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases. Parsaclisib displays significant activity with IC50 values ranging from 0.2 to 2 nM in B and T cell proliferation aaasys. Parsaclisib inhibits proliferation of several DLBCL and MCL cell lines in vitro (EC50< 10 nM)[1]. [1]. Niu Shin, et al. Abstract 2671: INCB050465, a novel PI3Kδ inhibitor, synergizes with PIM protein kinase inhibition to cause tumor regression in a model of DLBCL. Cancer Research. 2015, Aug. 75(15).