PfDHODH-IN-1 是一种 Leflunomide 活性代谢物的类似物。PfDHODH-IN-1 是一种恶性疟原虫二氢乳清酸脱氢酶 (PfDHODH) 抑制剂。PfDHODH-IN-1 具有抗疟疾活性。
| Cas No. | 183945-55-3 |
| 分子式 | C14H11F3N2O2 |
| 分子量 | 296.24 |
| 溶解度 | DMSO : 83.33 mg/mL (281.29 mM; ultrasonic and warming and heat to 60℃) |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PfDHODH-IN-1 is an analogue of the active metabolite of Leflunomide. PfDHODH-IN-1 is a Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor. PfDHODH-IN-1 has antimalarial activity[1][2]. [1]. Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12(5):2982-93.
[2]. Hou X, et al. QSAR study on the antimalarial activity of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors. SAR QSAR Environ Res. 2016;27(2):101-24. |
