CAS NO: | 2272976-28-8 |
包装 | 价格(元) |
5mg | 询价 |
10mg | 询价 |
25mg | 询价 |
Cas No. | 2272976-28-8 |
分子式 | C28H31N7O2 |
分子量 | 497.59 |
溶解度 | DMSO : 250 mg/mL (502.42 mM; Need ultrasonic) |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | WEE1-IN-3 is a potent Wee1 kinase inhibitor with an IC50 of<10 nM. WEE1-IN-3 has anticancer activities[1]. WEE1-IN-3 (example 1) inhibits cancer cell growth with IC50 values of 100-1000 nM and<100 nM for SW480 cells and H23 cells, respectively[1].WEE1 kinase plays a role in the G2-M cell-cycle checkpoint arrest for ?Να repair before mitotic entry. Normal cells repair damaged DNA during GI arrest. Cancer cells often have a deficient G i-S checkpoint and depend on a functional G2-M checkpoint for DNA repair. WEE1 is overexpressed in various cancer types[1]. [1]. Peter Qinhua HUANG, et al. 1, 2 - dihydro- 3h- pyrazolo [3, 4 - d] pyrimidin -3 - one analogs. WO2019028008A1. |
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