| 包装 | 价格(元) |
| 500 μg | 询价 |
| 1mg | 询价 |
| 别名 | LGD1069 D4 |
| Canonical SMILES | C=C(C1=C([2H])C([2H])=C(C(O)=O)C([2H])=C1[2H])C2=CC3=C(C=C2C)C(C)(C)CCC3(C)C |
| 分子式 | C24H24D4O2 |
| 分子量 | 352.5 |
| 溶解度 | DMF: 20 mg/ml,DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml,DMSO: 10 mg/ml,Ethanol: 0.5 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Bexarotene-d4is intended for use as an internal standard for the quantification of bexarotene by GC- or LC-MS. Bexarotene is a high-affinity ligand for retinoid X receptors (RXRs) (EC50s = 28, 25, and 20 nM for RXRα, β, and γ, respectively).1It inhibits cell cycle progression, induces apoptosis, prevents or overcomes multidrug resistance through multidrug resistance protein 1 (MDR1), and blocks angiogenesis and metastasis, making it a promising chemopreventive agent against cancer.2,3Bexarotene also, through RXR activation, stimulates clearance of soluble β-amyloid, reduces plaque area, and reverses deficits related to Alzheimer's disease in mice.4 1.Boehm, M.F., Zhang, L., Zhi, L., et al.Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cellsJ. Med. Chem.38(16)3146-3155(1995) 2.Bischoff, E.D., Gottardis, M.M., Moon, T.E., et al.Beyond tamoxifen: The retinoid X receptor-selective ligand LGD1069 (TARGRETIN) causes complete regression of mammary carcinomaCancer Res.58(3)479-484(1998) 3.Qu, L., and Tang, X.Bexarotene: A promising anticancer agentCancer Chemother. Pharmacol.65(2)201-205(2010) 4.Cramer, P.E., Cirrito, J.R., Wesson, D.W., et al.ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse modelsScience335(6057)1503-1506(2012) |
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