AUTEN-99（氢溴酸盐）是一种新型肌管蛋白磷酸酶 Jumpy（也称为 MTMR14）抑制剂。
| Cas No. | 1049780-58-6 |
| 别名 | Autophagy enhancer-99 hydrobromide |
| Canonical SMILES | N12C(SC(C3=CC=C(C4=CC=CC=C4)C=C3)=C2)=NCC1.Br |
| 分子式 | C17H14N2S.HBr |
| 分子量 | 359.3 |
| 溶解度 | DMSO: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | AUTEN-99 is an inhibitor of the phosphatase myotubularin-related protein 14 (MTMR14/Jumpy).1It inhibits MTMR14/Jumpy activity in a cell-free assay when used at concentrations of 10 and 100 µM. AUTEN-99 (1 and 10 µM) enhances autophagic flux and increases the levels of LC3B-11 in HeLa cells. It increases survival of mouse primary neurons exposed to hydrogen peroxide as a model of oxidative stress when used at concentrations ranging from 0.5 to 5 µM. AUTEN-99 increases the number of autophagic structures in mouse pancreas, kidney, and liver following oral or intraperitoneal administration. It also induces autophagy in theDrosophilalarval fat body and increases the percentage of flies climbing a glass column in a climbing assay in a transgenic model of Parkinson's disease. 1.KovÁcs, T., Billes, V., KomlÓs, M., et al.The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptomsSci. Rep.742014(2017) |
