Afatinibimpurity11是Afatinib的一种杂质，Afatinib是一种不可逆的EGFR家族抑制剂，抑制EGFRwt，EGFRL858R，EGFRL858R/T790M和HER2的IC50分别为0.5nM，0.4nM，10nM和14nM。
| Cas No. | 1402086-20-7 |
| Canonical SMILES | O=C(NC1=C(C=C2C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)=C1)O[C@H]4CCOC4)C=C |
| 分子式 | C21H18ClFN4O3 |
| 分子量 | 428.84 |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively[1]. [1]. Li D, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7;27(34):4702-11. |
