LC3-mHTT-IN-AN1 (Compound AN1) 是一种 mHTT-LC3 连接化合物，LC3-mHTT-IN-AN1 与突变型亨廷顿蛋白 (mHTT) 和 LC3B 相互作用，但不与 wtHTT 或无关的对照蛋白相互作用。LC3-mHTT-IN-AN1 以等位基因选择性的方式降低了亨廷顿病 (HD) 小鼠神经元中mHTT水平。
| Cas No. | 486443-73-6 |
| Canonical SMILES | BrC1=CC=C(C/2=C1)NC(C2=C/C3=CC(Br)=C(C(O)=C3)O)=O |
| 分子式 | C15H9Br2NO3 |
| 分子量 | 411.04 |
| 溶解度 | DMSO: 125 mg/mL (304.11 mM); Water:< 0.1 mg/mL (insoluble) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1]. [1]. Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209. |
