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LC3-mHTT-IN-AN2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LC3-mHTT-IN-AN2图片
CAS NO:7758-73-8

LC3-mHTT-IN-AN2 (Compound AN2) 是一种 mHTT-LC3 连接化合物,LC3-mHTT-IN-AN2 与突变型亨廷顿蛋白 (mHTT) 和 LC3B 相互作用,但不与 wtHTT 或无关的对照蛋白相互作用。LC3-mHTT-IN-AN2 以等位基因选择性的方式降低了亨廷顿病 (HD) 小鼠神经元中mHTT水平。
Cas No.7758-73-8
别名5,7-二羟基-4-苯基香豆素
Canonical SMILESOC1=C2C(OC(C=C2C3=CC=CC=C3)=O)=CC(O)=C1
分子式C15H10O4
分子量254.24
溶解度DMSO: 250 mg/mL (983.32 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

LC3-mHTT-IN-AN2 (Compound AN2) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1].

[1]. Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Oct 30.

 
 
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