| CAS NO: | 2055015-61-5 |
| Cas No. | 2055015-61-5 |
| Canonical SMILES | O=S(C1=CC=C(OC(F)(F)F)C=C1)(C2=CN=C(C(NC[C@@H](O)C)=O)C(N)=C2)=O |
| 分子式 | C16H16F3N3O5S |
| 分子量 | 419.38 |
| 溶解度 | DMSO: 270 mg/mL (643.81 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM[1]. Cystic fibrosis transmembrane conductance regulator[1] GLPG2451 has an EC50 value of 675 nM and an efficacy level of 147% of that of VX770 in G551D/F508del cells[1]. [1]. Gees M, et al. Identification and Characterization of Novel CFTR Potentiators. Front Pharmacol. 2018 Oct 26;9:1221. |
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