CFTR 校正剂 1 (VX-445, Compound 1) 是囊性纤维化跨膜电导调节剂 (CFTR) 的调节剂。
| Cas No. | 2216712-66-0 |
| 别名 | VX-445 |
| Canonical SMILES | CC1(C)C[C@H](C)CN1C2=C(C(NS(C3=CN(C)N=C3C)(=O)=O)=O)C=CC(N4C=CC(OCC(C)(C(F)(F)F)C)=N4)=N2 |
| 分子式 | C26H34F3N7O4S |
| 分子量 | 597.65 |
| 溶解度 | DMSO: 125 mg/mL (209.15 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CFTR corrector 1 (compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). CFTR corrector 1 (compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface[1].
CFTR[1]. [1]. Alexander Russell Abela, et al. MODULATOR OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR , PHARMACEUTICAL COMPOSITIONS , METHODS OF TREATMENT , AND PROCESS FOR MAKING THE MODULATOR. US 20180162839 A1. |
