| CAS NO: | 2127109-84-4 |
| Cas No. | 2127109-84-4 |
| Canonical SMILES | N#CC[C@@]1(N2N=CC(C3=NC(C4=CN(C)N=C4)=CN5C3=CC=N5)=C2)C[C@H](C#N)C1 |
| 分子式 | C20H17N9 |
| 分子量 | 383.41 |
| 溶解度 | DMSO: 16.67 mg/mL (43.48 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Tyk2-IN-8 (compound 10) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain with an IC50 of 17 nM, used in the treatment of psoriasis[1]. IC50: 17 nM (TYK2 JH1)[1] Tyk2-IN-8 also inhibits JAK1 (IC50=74 nM) and JAK2 (IC50=383 nM)[1]. [1]. Wrobleski ST, et al. Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J Med Chem. 2019 Jul 18. |
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