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Mutated EGFR-IN-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Mutated EGFR-IN-1图片
CAS NO:1421372-66-8

Mutated EGFR-IN-1是突变型EGFR（L858R EGFR，Exonl9缺失活化突变和T790M抗性突变）抑制剂的中间体。
Cas No.1421372-66-8
别名AZD9291中间体1,Osimertinib analog
Canonical SMILESNC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C
分子式C25H31N7O
分子量445.56
溶解度DMSO: ≥ 75 mg/mL (168.33 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Mutated EGFR-IN-1 is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant.IC50 value:Target: Mutated EGFR inhibitorMore information can be found in Patent WO 2013014448 A1.2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer. EGFRL858R EGFRExon 19 deletion/T790M EGFRT790M

[1]. Patent WO 2013014448 A1. 2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer.

 
 
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