EGFR-IN-7 (compound 34) 是一种有效选择性的 EGFR 激酶抑制剂，对 EGFR (WT) 和 EGFR (mutant C797S/T790M/L858R) 的 IC50 值分别为 7.92 nM 和 0.218 nM，具有抗肿瘤活性，详细信息请参考专利 WO2019015655A1。
| Cas No. | 2267329-76-8 |
| 别名 | 5-溴-N4-[5-(二甲基膦基)-6-喹喔啉基]-N2-[2-甲氧基-5-甲基-4-[4-(4-甲基-1-哌嗪基)-1-哌啶基]苯基]-2,4-嘧啶二胺 |
| Canonical SMILES | CN1CCN(C2CCN(C3=C(C)C=C(NC4=NC=C(Br)C(NC5=CC=C6N=CC=NC6=C5P(C)(C)=O)=N4)C(OC)=C3)CC2)CC1 |
| 分子式 | C32H41BrN9O2P |
| 分子量 | 694.6 |
| 溶解度 | DMSO: 5 mg/mL (7.20 mM; ultrasonic and warming and adjust pH to 5 with 0.1 M HCL and heat to 60℃) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | EGFR-IN-7 (compound 34) is a selective and potent EGFR kinase inhibitor extracted from patent WO2019015655A1, has IC50s of 7.92 nM and 0.218 nM for EGFR (WT) and EGFR (mutant C797S/T790M/L858R) respectively, and shows anti-tumor activity[1].
EGFR (WT)|7.92 nM (IC50)|EGFR (C797S/T790M/L858R)|0.218 nM (IC50) [1]. Aryl-phosphorus-oxygen compound as egfr kinase inhibitor. |
