EGFR-IN-3 是第三代 EGFR TKI，GI50 值分别为 5 nM (EGFR L858R/T790M)、10 nM (EGFR del19) 和 689 nM (EGFR WT)。 EGFR-IN-3 具有用于 NSCLC 研究的潜力。
| Cas No. | 1660963-42-7 |
| Canonical SMILES | OCCN1CCN(C2=C(F)C(F)=C(NC3=NC=C4C(C(C5=CC(NC(C=C)=O)=CC=C5)=CC=C4)=N3)C=C2)CC1 |
| 分子式 | C29H28F2N6O2 |
| 分子量 | 530.57 |
| 溶解度 | DMSO : 125 mg/mL (235.60 mM);Water :< 0.1 mg/mL (insoluble) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | EGFR-IN-3 is an epidermal growth factor receptor (EGFR) inhibitor. |
