三甲胺 N-氧化物是膳食胆碱和其他含三甲胺营养素的肠道微生物依赖性代谢物。
| Cas No. | 1184-78-7 |
| 别名 | 三甲胺N-氧化物 |
| Canonical SMILES | C[N](C)(C)=O |
| 分子式 | C3H9NO |
| 分子量 | 75.1 |
| 溶解度 | DMF: 1 mg/ml,DMSO: 1 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Trimethylamine N-oxide (TMAO) is a product of the oxidation of TMA by flavin-containing mono-oxygenase 3 in the liver. TMAO levels predict risk for atherosclerosis and are elevated in patients with chronic kidney disease and obesity. TMAO levels are decreased in ulcerative colitis. TMAO increases atherosclerosis in ApoE-/- mice, suggesting that TMAO can directly induce cardiovascular disease. The biosynthesis of TMA is dependent on gut bacteria, providing a link between the biome and cardiovascular disease. |
