Ibrutinib D5 (PCI-32765 D5) 是 Ibrutinib 的一种氘代化合物。Ibrutinib 是一种选择性，不可逆的 Btk 抑制剂。
| Cas No. | 1553977-17-5 |
| 别名 | 伊布替尼布D5,PCI-32765-d5 |
| Canonical SMILES | C=CC(N1C[C@H](N2N=C(C3=CC=C(OC4=C([2H])C([2H])=C([2H])C([2H])=C4[2H])C=C3)C5=C(N)N=CN=C52)CCC1)=O |
| 分子式 | C25H19D5N6O2 |
| 分子量 | 445.53 |
| 溶解度 | DMF: 30mg/ml,DMSO: 30mg/ml,Ethanol: 0.25mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Ibrutinib D5 (PCI-32765 D5) is a deuterium labeled Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor[1]. [1]. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80. |
