MK-0429(L-000845704)

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CAS NO:

227963-15-7

MK-0429 (L-000845704) (L-000845704) 是一种具有口服活性的、有效的、选择性的非肽类泛整合素拮抗剂，对于 α 的 IC50 值为 1.6 nM、2.8 nM、0.1 nM、0.7 nM、0.5 nM 和 12.2 nM ;vβ1, αvβ3, αvβ5, αvβ6, αvβ8 and α5β1, respectively.

Cas No.	227963-15-7
别名	L-000845704
Canonical SMILES	O=C1N([C@H](C2=CC=C(OC)N=C2)CC(O)=O)CCN1CCCC3=NC4=C(C=C3)CCCN4
分子式	C₂₃H₂₉N₅O₄
分子量	439.51
溶解度	DMSO : 250 mg/mL (568.82 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	MK-0429 is a potent integrin antagonist with IC50s of 12.2 nM (α5β1 integrin) and 2.8 nM (αvβ3 integrin), respectively. [1]. Zhou X, et al. An integrin antagonist (MK-0429) decreases proteinuria and renal fibrosis in the ZSF1 rat diabetic nephropathy model.Pharmacol Res Perspect. 2017 Oct; 5 (5).