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Binodenoson
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Binodenoson图片
CAS NO:144348-08-3
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包装价格(元)
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Binodenoson (MRE-0470) 是一种有效且选择性 A2A 腺苷受体激动剂(KD=270 nM)。Binodenoson 是一种短效冠状动脉扩张剂，作为放射性示踪剂的辅助物，用于心肌负荷显像。
Cas No.144348-08-3
别名比诺地松,MRE-0470; WRC 0470
分子式C17H25N7O4
分子量391.42
溶解度DMSO : 125 mg/mL (319.35 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Binodenoson (MRE-0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stress imaging[1].

Binodenoson (MRE-0470) (30-300 nM) decreases oxidative activity of tumor necrosis factor-α-primed FMLP-stimulated polymorphonuclear leukocytes in human whole blood and acts synergistically with Rolipram[1].

Binodenoson (infused 0-0.9 μg/kg/h; adult Wistar rat; rat bacterial meningitis model), with or without rolipram (0-0.01 μg/kg/h), inhibits pleocytosis and reduces the lipopolysaccharide-induced increase in blood-brain barrier permeability (BBBP), indicative of decreased neutrophil-induced damage[1].

[1]. Sullivan GW, et al. Neutrophil A2A adenosine receptor inhibits inflammation in a rat model of meningitis: synergy with the type IV phosphodiesterase inhibitor, rolipram. J Infect Dis. 1999;180(5):1550-1560.
[2]. Glover DK, et al. Pharmacological stress thallium scintigraphy with 2-cyclohexylmethylidenehydrazinoadenosine (WRC-0470). A novel, short-acting adenosine A2A receptor agonist. Circulation. 1996;94(7):1726-1732.

 
 
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