α-Methylserotonin 是5-HT2受体的有效和选择性激动剂。α-Methylserotonin 是由α-甲基色氨酸在体内形成的5-羟色胺类似物。α-Methylserotonin 介导淋巴平滑肌收缩并防止血清素受体介导的磷酸肌醇水解的上调。
| Cas No. | 304-52-9 |
| 别名 | Α-甲基-5-羟色胺马来酸盐 |
| 分子式 | C11H14N2O |
| 分子量 | 190.24 |
| 溶解度 | Methanol : 62.5 mg/mL (328.53 mM; ultrasonic and warming and heat to 60℃)|DMSO : 50 mg/mL (262.83 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | α-Methylserotonin is a potent and selective agonist of 5-HT2 receptor.α-Methylserotonin is an analogue of serotonin formed in vivo from α-methyltryptophan.α-Methylserotonin mediates the lymphatic smooth muscle contraction and prevents the up-regulation of serotonin-receptor-mediated phosphoinositide hydrolysis[1][2][3]. [1]. Dobbins DE. Receptor mechanisms of serotonin-induced prenodal lymphatic constriction in the canine forelimb. Am J Physiol. 1998 Feb;274(2):H650-4.
[2]. Brumley MR, et al. The serotonergic agonists quipazine, CGS-12066A, and alpha-methylserotonin alter motor activity and induce hindlimb stepping in the intact and spinal rat fetus. Behav Neurosci. 2005 Jun;119(3):821-33.
[3]. Edwards E, et al. (+/-)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane(DOI) and alpha-methyl-5-HT: 5-HT2 receptor agonistic action on phosphatidylinositol metabolism in the rat fronto-cingulate and entorhinal cortex. Neuropharmacology. 1992 Jul;31(7):615-21. |
