MRTX-EX185 是负载 GDP 的 KRAS 和 KRAS(G12D) 的有效抑制剂，对 KRAS(G12D) 的 IC50 值为 90 nM。MRTX-EX185 还结合 GDP 负载的 HRAS。
| 分子式 | C33H33FN6O2 |
| 分子量 | 564.65 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | MRTX-EX185 is a potent inhibitor of GDP-loaded KRAS and KRAS(G12D), with an IC50 of 90 nM for KRAS(G12D). MRTX-EX185 also binds GDP-loaded HRAS[1]. [1]. Vasta JD, et, al. KRAS is vulnerable to reversible switch-II pocket engagement in cells. Nat Chem Biol. 2022 Mar 21. |
