A small molecule promotor of hepatocyte differentiation
| Cas No. | 2719-05-3 |
| Canonical SMILES | CC(NC1=CC=C(CC2=CC=C(NC(C)=O)C=C2)C=C1)=O |
| 分子式 | C17H18N2O2 |
| 分子量 | 282.3 |
| 溶解度 | DMF: 2 mg/ml,DMSO: 5 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 0.5 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | BRD-K4477, also known as functional hits 1 (FH1), is a small molecule promotor of hepatocyte differentiationin vitro.1It induces maturation of hepatocyte-like cells (iHeps) to a more adult-like liver phenotype in a concentration-dependent manner. BRD-K4477 increases albumin secretion and promotes hepatocyte morphologies including polygonal cell shapes, visible nuclei, and formation of bile canaliculi in iHeps. It also increases expression of ABCB11 and bile-salt export pump (BSEP) mRNA as well as activity of the mature cytochrome P450 (CYP) isoforms CYP3A and CYP2A6 in iHeps. 1.Shan, J., Schwartz, R.E., Ross, N.T., et al.Identification of small molecules for human hepatocyte expansion and iPS differentiationNat. Chem. Biol.9(8)514-520(2013) |
