YAP-TEAD TFA 是 YAP-TEAD 相互作用的有效的竞争性肽类抑制剂 (IC50=25 nM)。YAP-TEAD TFA 是一种 17mer 的多肽，与 YAP (50-171) (Kd=40 nM) 相比，其与 TEAD1 的结合亲和力更高 (Kd= 15 nM)。
| Cas No. | 1659305-79-9 |
| 分子式 | C93H144ClN23O21S2.xC2HF3O2 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | YAP-TEAD TFA is a potent and competitive peptide inhibitor of YAP-TEAD interaction (IC50=25 nM). YAP-TEAD TFA is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd= 40 nM)[1]. [1]. Zhang Z, et al. Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.ACS Med Chem Lett. 2014 Jul 14;5(9):993-8. |
