Cyclopamine-KAAD 是一种刺猬信号抑制剂，是一种平滑拮抗剂。
| Cas No. | 306387-90-6 |
| 别名 | 3-酮-N-氨基乙基-N'-氨基己酰二氢肉桂酰环杷明,Cyclopamine-KAAD |
| Canonical SMILES | CC1=C2[C@](CC[C@@]31O[C@@](C[C@H](C)CN4CCNC(CCCCCNC(CCC5=CC=CC=C5)=O)=O)([H])[C@]4([H])[C@H]3C)([H])[C@]6([H])CC=C7CC(CC[C@]7(C)[C@@]6([H])C2)=O |
| 分子式 | C44H63N3O4 |
| 分子量 | 698 |
| 溶解度 | Chloroform: Slightly soluble,Methanol: Slightly soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Cyclopamine-KAAD is a potent inhibitor of hedgehog signaling with an IC50 value of 20 nM in a Shh-LIGHT2 assay. It blocks binding of BODIPY-cyclopamine to cells expressing Smoothened (Smo) in a dose-dependent manner. Cyclopamine-KAAD is cell-permeable and binds to SmoA1 to promote its exit from the endoplasmic reticulum. It inhibits the invasion and migration (45.9 and 43.3% inhibition, respectively) of Bel-7402 hepatocarcinoma cells and decreases the expression of nuclear glioma-associated oncogene 1 (Gli1) and cytosolic MMP-9, pERK1, and pERK2 proteins in a dose-dependent manner. Cyclopamine-KAAD also increases TRAIL-mediated cell death in NCH82 and NCH89 human glioblastoma cultures and upregulates expression of the death receptors DR4 and DR5 in LN229 and U251 glioma cells. |
