ABC99 是一种 N-羟基乙内酰脲 (NHH) 氨基甲酸酯，可选择性抑制 Wnt 脱酰酶 NOTUM (IC50=13 nM)。 ABC99 在 NOTUM 存在的情况下保留 Wnt3A 信号。
| Cas No. | 2331255-53-7 |
| 化学名 | 7-(4-chlorobenzyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl-2,3-dihydro-4H-benzo[b][1,4]oxazine-4-carboxylate |
| Canonical SMILES | ClC1=CC=C(CN2CC(C(N(OC(N3C(C=CC=C4)=C4OCC3)=O)C5=O)=O)N5CC2)C=C1 |
| 分子式 | C22H21ClN4O5 |
| 分子量 | 456.9 |
| 溶解度 | 1mg/mL in Chloroform, 1mg/mL in acetonitrile, 1mg/mL in methyl acetate |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ABC99 is an N-hydroxyhydantoin (NHH) carbamate that inhibits the Wnt-deacylating enzyme NOTUM (IC50 = 13 nM).[1] It preserves Wnt3A signaling in the presence of NOTUM (EC50 = 89 nM in a cell-based reporter assay). Reference:
[1]. Suciu, R.M., Cognetta, A.B., III., Potter, Z.E., et al. Selective irreversible inhibitors of the Wnt-deacylating enzyme NOTUM developed by activity-based protein profiling. ACS Med. Chem. Lett. 9(6), 563-568 (2018). |
