IWP-O1是一个有效的Porcn抑制剂，其在L-Wnt-STF细胞中测得的EC50值为80pM。能够抑制HeLa细胞中Dvl2/3和LRP6的磷酸化。IWP-O1通过抑制Wnt蛋白的分泌发挥作用。
| Cas No. | 2074607-48-8 |
| Canonical SMILES | O=C(CN1N=NC(C2=CC=NC=C2)=C1C3=CC=CC=C3)NC4=NC=C(C5=CC=CC=C5)C=C4 |
| 分子式 | C26H20N6O |
| 分子量 | 432.48 |
| 溶解度 | DMSO : 125 mg/mL (289.03 mM);Water :< 0.1 mg/mL (insoluble) |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells, suppressing the phosphorylation of Dvl2/3 and LRP6 in HeLa cells. IWP-O1 functions by preventing the secretion of Wnt proteins[1].
EC50: 80 pM (Porcn)[1]. [1]. You L, et al. Development of a triazole class of highly potent Porcn inhibitors. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895. |
