CK1-IN-1是一种酪蛋白激酶1(CK1)抑制剂，对CK1δ、CK1ε、p38σMAPK的IC50值为15nM,16nM,73nM，详细信息请参考专利WO2015119579A1，化合物1c。
| Cas No. | 1784751-20-7 |
| Canonical SMILES | FC1=CC=C(C2=C(C3=CC=NC=C3)NC(C4=CC=C5C=CC=CC5=C4F)=N2)C=C1 |
| 分子式 | C24H15F2N3 |
| 分子量 | 383.39 |
| 溶解度 | DMSO : 62.5 mg/mL (163.02 mM);Water :< 0.1 mg/mL (insoluble) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CK1-IN-1 is a casein kinase 1 (CK1) inhibitor extracted from patent WO2015119579A1, compound 1c, has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MAPK, respectively[1].
CKIδ|15 nM (IC50)|CK1?|16 nM (IC50) [1]. Filip LACO,et al. 2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis. WO2015119579A1. |
