JS-K 是一种 NO 供体，在生理 pH 值下与谷胱甘肽反应生成 NO。 JS-K 抑制 Jurkat T 急性淋巴细胞白血病细胞的增殖、诱导细胞凋亡并破坏细胞周期。
| Cas No. | 205432-12-8 |
| 化学名 | 4-[2-(2,4-dinitrophenoxy)-1-oxidodiazenyl]-1-piperazinecarboxylic acid, ethyl ester |
| Canonical SMILES | O=[N](N1CCN(C(OCC)=O)CC1)=NOC(C=CC([N+]([O-])=O)=C2)=C2[N+]([O-])=O |
| 分子式 | C13H16N6O8 |
| 分子量 | 384.3 |
| 溶解度 | DMF: 0.5 mg/ml,DMSO: 0.3 mg/ml,Ethanol: slightly soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | JS-K is a nitric oxide (NO) donor that reacts with glutathione to generate NO at physiological pH. It inhibits proliferation of HL-60 cells (IC50 = 0.5 uM), which is prevented by the glutathione precursor N-acetyl-L-cysteine , and inhibits growth of the solid tumor cell lines PPC-1, DLD-1, and Meth A. It decreases tumor volume by over 50% in an HL-60 mouse xenograft model when used at a dose of 4 uMol/kg, i.v., three times per week. JS-K inhibits proliferation, induces apoptosis, and disrupts the cell cycle of Jurkat T acute lymphoblastic leukemia cells. It also induces S-nitrosylation of β-catenin followed by dose-dependent degradation of nuclear β-catenin and S-nitrosylated nuclear β-catenin levels. |
