JW 67 抑制经典 Wnt 信号传导，IC50 为 1.17μM。 JW 67 影响由 β-catenin/GSK-3β/AXIN/APC/CK1 组成的多蛋白复合物，该复合物迅速降低活性 β-catenin，随后下调 Wn\u200b\u200bt 靶基因。 JW 67 还抑制结直肠癌细胞的生长。
| Cas No. | 442644-28-2 |
| Canonical SMILES | OC1=NC2=CC=CC=C2C13OCC(COC45C6=CC=CC=C6N=C4O)(CO5)CO3 |
| 分子式 | C21H18N2O6 |
| 分子量 | 394.38 |
| 溶解度 | <39.44mg/ml in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
