ISX 9 (Isoxazole 9) 是成人神经干细胞分化的有效诱导剂。
| Cas No. | 832115-62-5 |
| 别名 | Isoxazole 9 |
| 化学名 | N-cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide |
| Canonical SMILES | O=C(C1=NOC(C2=CC=CS2)=C1)NC3CC3 |
| 分子式 | C11H10N2O2S |
| 分子量 | 234.27 |
| 溶解度 | ≥ 23.4mg/mL in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ISX-9 is a small molecule inducer of adult neural stem cell differentiation. Target: At 2.5-20 μM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor 2-dependent gene expression.ISX-9 administered at 20 mg/kg for 12 days to mice has been reported to improve hippocampal function as evidenced by enhanced spatial memory ability in the Morris water maze test. References:
[1]. Petrik D, et al. Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule. FASEB J. 2012 Aug;26(8):3148-3162. |
