首页 蛋白库 基因库 产品 会员服务
位置：首页 > 产品库 > Guanylin(human)(trifluoroacetate salt)
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Guanylin(human)(trifluoroacetate salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Guanylin(human)(trifluoroacetate salt)图片
包装与价格：
包装价格(元)
500 µg询价
1mg询价

A peptide hormone activator of GC-C
Canonical SMILESO=C(N[C@H](C(N[C@H](C(N[C@](CSSC[C@]1([H])NC([C@@]([C@H](O)C)([H])NC(CNC([C@@H]2CCCN2)=O)=O)=O)([H])C(N[C@@](C3=O)([H])[C@H](O)C)=O)=O)C)=O)C)[C@](NC([C@@H](NC([C@@](CSSC[C@H](NC(CN3)=O)C(O)=O)([H])NC(C(NC([C@@H](NC1=O)CCC(O)=O)=O)[C@@H](C)CC)=O)=O)C)=O)([H])CC(C=C4)=CC=C4O.OC(C(F)(F)F)=O
分子式C58H87N15O21S4·XCF3COOH
分子量1458.7
溶解度Water: 1 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Guanylin is a peptide hormone activator of membrane-bound guanylate cyclase C (GC-C).1,2It contains four cysteines that can form disulfide bridges leading to two possible isoforms, with the active form containing disulfide bridges between Cys4and Cys12and Cys7and Cys15.1Guanylin is found in epithelial cells of the small intestine where it activates GC-C to increase intestinal chloride and fluid secretion.2,3,4Guanylin expression is reduced by 100- to 1,000-fold in greater than 85% of isolated tumors from patients with colorectal cancer compared with adjacent non-cancerous intestinal epithelial tissue.5

1.Nokihara, K., Wray, V., Ando, E., et al.Synthesis, solution structure, binding activity, and cGMP activation of human guanylin and its disulfide isomerRegul. Pept.70(2-3)111-120(1997) 2.de Sauvage, F.J., Keshav, S., Kuang, W.-J., et al.Precursor structure, expression, and tissue distribution of human guanylinProc. Natl. Acad. Sci. USA89(19)9089-9093(1992) 3.Hill, O., Kuhn, M., Zucht, H.-D., et al.Analysis of the human guanylin gene and the processing and cellular localization of the peptideProc. Natl. Acad. Sci. USA92(6)2046-2050(1995) 4.Forte, L.R., and Currie, M.G.Guanylin: A peptide regulator of epithelial transportFASEB J.9(8)643-650(1995) 5.Wilson, C., Lin, J.E., Snook, A.E., et al.The paracrine hormone for the GUCY2C tumor suppressor, guanylin, is universally lost in colorectal cancerCancer Epidemiol. Biomarkers Prev.23(11)2328-2337(2014)

 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024