Avrainvillamide is a fungal metabolite and monomeric form of stephacidin B that has been found inA. ochraceus.^1,2It is active againstS. aureus,S. pyogenes, andE. faecalis(MICs = 12.5, 12.5, and 25 µg/ml, respectively).²Avrainvillamide inhibits the growth of LNCaP, BT-549, T47D, and MALME-3M cancer cells with GI₅₀values of 0.24, 0.62, 0.21, and 0.41 µM, respectively.¹

1.Wulff, J.E., Herzon, S.B., Siegrist, R., et al.Evidence for the rapid conversion of stephacidin B into the electrophilic monomer avrainvillamide in cell cultureJ. Am. Chem. Soc.129(16)4898-4899(2007) 2.Sugie, Y., Hirai, H., Inagaki, T., et al.A new antibiotic CJ-17,665 from Aspergillus ochraceusJ. Antibiot.54(11)911-916(2001)