| 产品描述 | N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) is a tobacco-specific nitrosamine carcinogen.1It is oxidized to the reactive metabolite methyl-2-oxopropylnitrosamine (MOPN) in isolated rat liver mitochondria.2NMBA induces bladder transitional cell carcinomas in rats when administered in the drinking water at a concentration of 300 mg/L per day.3 1.Djordjevic, M.V., Brunnemann, K.D., and Hoffmann, D.Identification and analysis of a nicotine-derived N-nitrosamino acid and other nitrosamino acids in tobaccoCarcinogenesis10(9)1725-1731(1989)
2.Janzowski, C., Landsiedel, R., GÖlzer, P., et al.Mitochondrial formation of β-oxopropyl metabolites from bladder carcinogenic ω-carboxyalkylnitrosaminesChem. Biol. Interact.90(1)23-33(1994)
3.Lijinsky, W., Reuber, M.D., Saavedra, J.E., et al.Carcinogenesis in F344 rats by N-nitrosomethyl-n-propylamine derivativesJ. Natl. Cancer Inst.70(5)959-963(1983) |
