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7α-Thiospironolactone
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
7α-Thiospironolactone图片
CAS NO:38753-76-3
包装与价格：
包装价格(元)
500 µg询价
1mg询价
5mg询价
10mg询价

An active metabolite of spironolactone
Cas No.38753-76-3
Canonical SMILESC[C@@]12[C@@]3(OC(CC3)=O)CC[C@@]1([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H]4S)=CC(CC5)=O)C)([H])CC2
分子式C22H30O3S
分子量374.5
溶解度Ethanol: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

7α-Thiospironolactone (7α-Thio-SL) is an active metabolite of the synthetic steroid spironolactone.1In vivo, 7α-thio-SL (100 mg/kg) decreases plasma testosterone and estradiol levels in male dogs.2It reduces mercuric chloride-induced nephrocalcinosis and mortality in rats.3

1.Los, L.E., Coddington, A.B., Ramjit, H.G., et al.Identification of spironolactone metabolites in plasma and target organs of guinea pigsDrug Metab. Dispos.21(6)1086-1090(1993) 2.Menard, R.H., Loriaux, D.L., Bartter, F.C., et al.The effect of the administration of spironolactone on the concentration of plasma testosterone, estradiol and cortisol in male dogsSteroids31(6)771-782(1978) 3.Szabo, S., and Gagnon, M.J.The protective effect of sulfur-containing steroids against nephrocalcinosis induced by mercuric chloride in ratsGen. Pharmacol.14(2)269-272(1983)

 
 
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