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Secretin(rat)(trifluoroacetate salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
包装:1mg
市场价:3009元

A neuropeptide hormone
Canonical SMILESNC([C@H](C(C)C)NC([C@H](CC(C)C)NC(CNC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC(CNC([C@@H](NC([C@H](CO)NC([C@@H](N[H])CC1=CN=CN1)=O)=O)CC(O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
分子式C129H216N42O42•XCF3COOH
分子量3027.4
溶解度Water: 1 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Secretin is a neuropeptide hormone that regulates secretion from the stomach, pancreas, and liver.1,2It binds to the rat secretin receptor (SCT-R; Ki= 3.3 nM) and increases intracellular cAMP (EC50= 1 nM) in COS cells expressing rat SCT-R.3It also increases SCT-R phosphorylation 7.2-fold at a concentration of 0.1 μM. Secretin dose-dependently increases the volume of pancreatic secretion and inhibits gastric acid secretion induced by gastrin I in rats when administered at a dose of 100 pmol/kg per hour.4

1.Kopin, A.S., Wheeler, M.B., and Leiter, A.B.Secretin: Structure of the precursor and tissue distribution of the mRNAProc. Natl. Acad. Sci. U.S.A.87(6)2299-2303(1990) 2.Sekar, R., and Chow, B.K.Metabolic effects of secretinGen. Comp. Endocrinol.18118-24(2013) 3.Ozcelebi, F., Holtmann, M.H., Rentsch, R.U., et al.Agonist-stimulated phosphorylation of the carboxyl-terminal tail of the secretin receptorMol. Pharmacol.48(5)818-824(1995) 4.Solomon, T.E., Keire, D.A., Gong, P., et al.Receptor subtypes: Species variations in secretin affect potency for pancreatic but not gastric secretionPancreas26(3)300-305(2003)

 
 
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